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		<title>How Smoking Causes Lung Cancer - 版本历史</title>
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		<updated>2026-04-06T14:43:10Z</updated>
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		<id>https://www.8beauty.com/wiki/index.php?title=How_Smoking_Causes_Lung_Cancer&amp;diff=101918&amp;oldid=prev</id>
		<title>2013年7月28日 (日) 15:21 DesiratFrame2063</title>
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				<updated>2013-07-28T15:21:51Z</updated>
		
		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table class='diff diff-contentalign-left'&gt;
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				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;←上一版本&lt;/td&gt;
				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;2013年7月28日 (日) 15:21的版本&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot; &gt;第1行：&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;第1行：&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;−&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Lung cancer is a global &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;issue &lt;/del&gt;and it is the most &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;popular &lt;/del&gt;cancer on &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;earth&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Annually &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cases &lt;/del&gt;of lung cancer are sadly improving. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;It's &lt;/del&gt;become fast worse in developing and former socialist countries, where &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;smoking &lt;/del&gt;rate &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;is still &lt;/del&gt;high&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;, even though usage of tobacco has dropped in many high income countries&lt;/del&gt;. Everyone knows that smoking causes lung cancer but how smoking causes lung cancer is a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;issue &lt;/del&gt;that &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;no body &lt;/del&gt;really knows. In this specific article I'll explain how smoking causes lung cancer.A &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cigarette smoking &lt;/del&gt;is &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;really &lt;/del&gt;a very &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;intricate combination &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;various &lt;/del&gt;substances. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;A lot &lt;/del&gt;more than 4000 different compounds have &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;now &lt;/del&gt;been indentified in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;mainstream cigarette smoke&lt;/del&gt;. From these 4000 and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;a bit &lt;/del&gt;more compounds 60-70 are carciongens: heterocyclic hydrocarbons, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;N &lt;/del&gt;-heterocyclic amines, polycyclic aromatic hydrocarbons (PAH), D -nitrosamines, aromatic amines, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;natural &lt;/del&gt;compounds, aldehydes, inorganic compounds like hydrazine and some materials and free radicals &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;[http://quit-smoking-products.net/v2-cigs-walgreens-are-e-cigarette-cartridges-interchangeable/ e cigarette unhealthy]&lt;/del&gt;.Tobacco &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;includes &lt;/del&gt;a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;high &lt;/del&gt;level of N-nitrosamines and PAH-s, which are which are strong carciogens. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Different substances &lt;/del&gt;seem to have lower carciogenic potential. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Numerous &lt;/del&gt;studies have shown that PAH-s &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;may cause &lt;/del&gt;cancers in laboratory animals. PAH- are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;formed &lt;/del&gt;by partial combustion of tobacco. Studies &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;have &lt;/del&gt;also found that PAH-s &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;could connect to &lt;/del&gt;the DNA, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;developing &lt;/del&gt;mutagenic DNA adducts. And the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;formation &lt;/del&gt;of DNA adducts may be the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;major starting event &lt;/del&gt;of carciogenesis.The &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;concentration &lt;/del&gt;of N-nitrosamines in tobacco is fairly large &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;and heavy smokers have the highest exposure to these compounds&lt;/del&gt;. The tobacco-specific N -nitrosamines (TSNA), &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;generally &lt;/del&gt;the nicotine-derived NNK, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;will &lt;/del&gt;be the strongest respiratory toxins &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;identified &lt;/del&gt;in tobacco products. Both benign and malignant tumors are formed in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;rodents&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;mice &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;mice &lt;/del&gt;have &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;already &lt;/del&gt;been activated by NNK. The &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;focus &lt;/del&gt;of NNK in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;conventional &lt;/del&gt;smoke has &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;risen &lt;/del&gt;while those of benzo( a pyrene have decreased &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;because &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;1960s.The &lt;/del&gt;smoke of cigarettes also &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;includes &lt;/del&gt;lots of free radicals and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;oxidative damage is caused by &lt;/del&gt;free radicals. Both &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;particulate and &lt;/del&gt;gas phase are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;highly &lt;/del&gt;oxidative and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;therefore &lt;/del&gt;damage the lung. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Cigarette smoke &lt;/del&gt;also &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;triggers &lt;/del&gt;proinflammatory cytokines and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;employees triggered macrophagesand &lt;/del&gt;neutrophils to lung tissue.Cigarettes &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;have &lt;/del&gt;a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;very &lt;/del&gt;high levels of materials. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;About &lt;/del&gt;30 &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;materials &lt;/del&gt;have &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;already &lt;/del&gt;been &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;identified&lt;/del&gt;. Some &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;research indicates &lt;/del&gt;that metals are powerful initiators of the carcinogenic process, but can be &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;likely &lt;/del&gt;supporters during carcinogenesis. Cigarette smoke contains high &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;degrees &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cadmium, &lt;/del&gt;chromium and also nickel. Chromium &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;accumulates &lt;/del&gt;in the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;tobacco and &lt;/del&gt;lung smoking &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;may &lt;/del&gt;be the primary supply of cadmium exposure in individuals. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Unfortunately &lt;/del&gt;the contribution of the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;metals &lt;/del&gt;to lung cancer is poorly understood.&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Lung cancer is a global &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;problem &lt;/ins&gt;and it is the most &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;typical &lt;/ins&gt;cancer on &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;the planet&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Each year &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;incidences &lt;/ins&gt;of lung cancer are sadly improving. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Even though the utilization of tobacco has dropped in lots of high income countries, it has &lt;/ins&gt;become fast worse in developing and former socialist countries, where &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;[http://www.auctionitmelbourne.com/about_me.php?user_id=100042 e cigarette forum volcano] &lt;/ins&gt;rate &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;continues to be &lt;/ins&gt;high. Everyone &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;else &lt;/ins&gt;knows that smoking causes lung cancer but how smoking causes lung cancer is &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;just &lt;/ins&gt;a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;question &lt;/ins&gt;that &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;nobody &lt;/ins&gt;really knows. In this specific article I'll explain how smoking causes lung cancer.A &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;cigarettes &lt;/ins&gt;is &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;just &lt;/ins&gt;a very &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;complicated blend &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;different &lt;/ins&gt;substances. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Significantly &lt;/ins&gt;more than 4000 different compounds have &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;already &lt;/ins&gt;been indentified in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;conventional cigarettes&lt;/ins&gt;. From these 4000 and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;much &lt;/ins&gt;more compounds 60-70 are carciongens: heterocyclic hydrocarbons, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Deborah &lt;/ins&gt;-heterocyclic amines, polycyclic aromatic hydrocarbons (PAH), D -nitrosamines, aromatic amines, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;normal &lt;/ins&gt;compounds, aldehydes, inorganic compounds like hydrazine and some materials and free radicals.Tobacco &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;contains &lt;/ins&gt;a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;large &lt;/ins&gt;level of N-nitrosamines and PAH-s, which are which are strong carciogens. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Other ingredients &lt;/ins&gt;seem to have lower carciogenic potential. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Various &lt;/ins&gt;studies have shown that PAH-s &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;can induce &lt;/ins&gt;cancers in laboratory animals. PAH- are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;produced &lt;/ins&gt;by partial combustion of tobacco. Studies also &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;have &lt;/ins&gt;found that PAH-s &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;may communicate with &lt;/ins&gt;the DNA, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;forming &lt;/ins&gt;mutagenic DNA adducts. And the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;synthesis &lt;/ins&gt;of DNA adducts may be the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;primary initiating function &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;heavy smokers have the greatest experience of these ingredients and &lt;/ins&gt;carciogenesis.The &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;focus &lt;/ins&gt;of N-nitrosamines in tobacco is fairly large. The tobacco-specific N -nitrosamines (TSNA), &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;primarily &lt;/ins&gt;the nicotine-derived NNK, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;would &lt;/ins&gt;be the strongest respiratory toxins &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;discovered &lt;/ins&gt;in tobacco products. Both benign and malignant tumors are formed in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;rats&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;hamsters &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;rats &lt;/ins&gt;have been activated by NNK. The &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;awareness &lt;/ins&gt;of NNK in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;main-stream &lt;/ins&gt;smoke has &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;improved &lt;/ins&gt;while those of benzo( a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;) &lt;/ins&gt;pyrene have decreased &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;since &lt;/ins&gt;the smoke of cigarettes also &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;incorporates &lt;/ins&gt;lots of free radicals and free radicals &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;cause oxidative injury&lt;/ins&gt;. Both &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;the &lt;/ins&gt;gas&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;-&lt;/ins&gt;phase &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;and particulate &lt;/ins&gt;are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;very &lt;/ins&gt;oxidative and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;for that reason &lt;/ins&gt;damage the lung. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Cigarettes &lt;/ins&gt;also &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;induces &lt;/ins&gt;proinflammatory cytokines and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;recruits activated macrophages&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;and &lt;/ins&gt;neutrophils to lung tissue.Cigarettes &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;include &lt;/ins&gt;a high levels of materials. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Somewhere around &lt;/ins&gt;30 &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;metals &lt;/ins&gt;have &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;now &lt;/ins&gt;been &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;discovered&lt;/ins&gt;. Some &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;evidence shows &lt;/ins&gt;that metals are powerful initiators of the carcinogenic process, but can be &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;possible &lt;/ins&gt;supporters during carcinogenesis. Cigarette smoke contains high &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;quantities &lt;/ins&gt;of chromium&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;, cadmium &lt;/ins&gt;and also nickel. Chromium &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;collects &lt;/ins&gt;in the lung &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;and cigarette &lt;/ins&gt;smoking &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;could &lt;/ins&gt;be the primary supply of cadmium exposure in individuals. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Unfortuitously &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;complete &lt;/ins&gt;contribution of the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;materials &lt;/ins&gt;to lung cancer is poorly understood.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;

&lt;!-- diff cache key 8bwiki:diff:version:1.11a:oldid:55726:newid:101918 --&gt;
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		<author><name>DesiratFrame2063</name></author>	</entry>

	<entry>
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		<title>2013年5月1日 (三) 09:08 DouglassFell888</title>
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				<updated>2013-05-01T09:08:50Z</updated>
		
		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table class='diff diff-contentalign-left'&gt;
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				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;←上一版本&lt;/td&gt;
				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;2013年5月1日 (三) 09:08的版本&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot; &gt;第1行：&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;第1行：&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;−&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Lung cancer is &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;just &lt;/del&gt;a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;world wide problem &lt;/del&gt;and it is the most &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;typical &lt;/del&gt;cancer on the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;planet. The &lt;/del&gt;cases of lung cancer are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;unfortuitously increasing every year&lt;/del&gt;. It &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;has &lt;/del&gt;become &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;swiftly &lt;/del&gt;worse in developing and former socialist countries, where smoking rate is still high, even though &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;the &lt;/del&gt;usage of tobacco has &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;decreased &lt;/del&gt;in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;several &lt;/del&gt;high income countries. Everyone knows that smoking causes lung cancer but how smoking causes lung cancer is a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;problem &lt;/del&gt;that no &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;one &lt;/del&gt;really knows. In this &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;essay &lt;/del&gt;I &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;will &lt;/del&gt;explain how smoking causes lung cancer.A cigarette smoking is a very intricate &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;mixture &lt;/del&gt;of various &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;compounds&lt;/del&gt;. A lot more than 4000 different compounds have &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;already &lt;/del&gt;been indentified in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;main-stream &lt;/del&gt;cigarette smoke. From these 4000 and a bit more compounds 60-70 are carciongens: heterocyclic hydrocarbons, N -heterocyclic amines, polycyclic aromatic hydrocarbons (PAH), &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;N &lt;/del&gt;-nitrosamines, aromatic amines, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;normal &lt;/del&gt;compounds, aldehydes, inorganic compounds like hydrazine and some materials and free radicals.Tobacco &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;contains &lt;/del&gt;a high &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;number &lt;/del&gt;of N-nitrosamines and PAH-s, which are which are strong carciogens. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Other compounds appear &lt;/del&gt;to have lower carciogenic potential. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Various &lt;/del&gt;studies have shown that PAH-s may cause &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;tumors &lt;/del&gt;in laboratory animals. PAH- are formed by &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;imperfect &lt;/del&gt;combustion of tobacco. Studies have also found that PAH-s could connect to the DNA, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;building &lt;/del&gt;mutagenic DNA adducts. And the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;synthesis &lt;/del&gt;of DNA adducts &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;will &lt;/del&gt;be the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;key initiating &lt;/del&gt;event of carciogenesis.The &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;focus &lt;/del&gt;of N-nitrosamines in tobacco is &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;relatively &lt;/del&gt;large and heavy smokers have the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;greatest &lt;/del&gt;exposure to these &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;ingredients&lt;/del&gt;. The tobacco-specific N -nitrosamines (TSNA), &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;principally &lt;/del&gt;the nicotine-derived NNK, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;are &lt;/del&gt;the strongest respiratory &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;carcinogens discovered &lt;/del&gt;in tobacco products. Both &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;malignant and &lt;/del&gt;benign tumors are formed in rodents, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;rats &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;hamsters &lt;/del&gt;have already been &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;induced &lt;/del&gt;by NNK. The &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;awareness &lt;/del&gt;of NNK in conventional smoke has &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;increased &lt;/del&gt;while those of benzo( a pyrene have &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;diminished since &lt;/del&gt;the 1960s.The smoke of cigarettes also &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;incorporates a lot &lt;/del&gt;of free radicals and oxidative damage is caused by free radicals. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;The &lt;/del&gt;particulate and gas phase are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;extremely &lt;/del&gt;oxidative and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;for that reason &lt;/del&gt;damage the lung. Cigarette &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;smoking &lt;/del&gt;also triggers proinflammatory cytokines and employees &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;activated &lt;/del&gt;macrophagesand neutrophils to lung tissue.Cigarettes &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;contain &lt;/del&gt;a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;quite &lt;/del&gt;high &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;degrees &lt;/del&gt;of materials. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Around &lt;/del&gt;30 materials have already been identified. Some &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;evidence &lt;/del&gt;indicates that &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;materials &lt;/del&gt;are powerful initiators of the carcinogenic process, but can &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;also &lt;/del&gt;be likely &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;promoters &lt;/del&gt;during carcinogenesis. Cigarette smoke contains high &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;levels &lt;/del&gt;of cadmium, chromium and also nickel. Chromium &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;collects &lt;/del&gt;in the lung &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;and tobacco &lt;/del&gt;smoking &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;could &lt;/del&gt;be the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;main source &lt;/del&gt;of cadmium exposure in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;humans&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Regrettably &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;factor &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;those materials &lt;/del&gt;to lung cancer is poorly understood &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;[http://www.bestejuice.net/e-cigar-review-essential-details-in-vapor-cigarette-refills-considered-e-cigar-review/ e cigarette carrying case]&lt;/del&gt;.&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Lung cancer is a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;global issue &lt;/ins&gt;and it is the most &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;popular &lt;/ins&gt;cancer on &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;earth. Annually &lt;/ins&gt;the cases of lung cancer are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;sadly improving&lt;/ins&gt;. It&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;'s &lt;/ins&gt;become &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;fast &lt;/ins&gt;worse in developing and former socialist countries, where smoking rate is still high, even though usage of tobacco has &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;dropped &lt;/ins&gt;in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;many &lt;/ins&gt;high income countries. Everyone knows that smoking causes lung cancer but how smoking causes lung cancer is a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;issue &lt;/ins&gt;that no &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;body &lt;/ins&gt;really knows. In this &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;specific article &lt;/ins&gt;I&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;'ll &lt;/ins&gt;explain how smoking causes lung cancer.A cigarette smoking is &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;really &lt;/ins&gt;a very intricate &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;combination &lt;/ins&gt;of various &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;substances&lt;/ins&gt;. A lot more than 4000 different compounds have &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;now &lt;/ins&gt;been indentified in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;mainstream &lt;/ins&gt;cigarette smoke. From these 4000 and a bit more compounds 60-70 are carciongens: heterocyclic hydrocarbons, N -heterocyclic amines, polycyclic aromatic hydrocarbons (PAH), &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;D &lt;/ins&gt;-nitrosamines, aromatic amines, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;natural &lt;/ins&gt;compounds, aldehydes, inorganic compounds like hydrazine and some materials and free radicals &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;[http://quit-smoking-products.net/v2-cigs-walgreens-are-e-cigarette-cartridges-interchangeable/ e cigarette unhealthy]&lt;/ins&gt;.Tobacco &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;includes &lt;/ins&gt;a high &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;level &lt;/ins&gt;of N-nitrosamines and PAH-s, which are which are strong carciogens. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Different substances seem &lt;/ins&gt;to have lower carciogenic potential. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Numerous &lt;/ins&gt;studies have shown that PAH-s may cause &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;cancers &lt;/ins&gt;in laboratory animals. PAH- are formed by &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;partial &lt;/ins&gt;combustion of tobacco. Studies have also found that PAH-s could connect to the DNA, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;developing &lt;/ins&gt;mutagenic DNA adducts. And the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;formation &lt;/ins&gt;of DNA adducts &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;may &lt;/ins&gt;be the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;major starting &lt;/ins&gt;event of carciogenesis.The &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;concentration &lt;/ins&gt;of N-nitrosamines in tobacco is &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;fairly &lt;/ins&gt;large and heavy smokers have the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;highest &lt;/ins&gt;exposure to these &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;compounds&lt;/ins&gt;. The tobacco-specific N -nitrosamines (TSNA), &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;generally &lt;/ins&gt;the nicotine-derived NNK, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;will be &lt;/ins&gt;the strongest respiratory &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;toxins identified &lt;/ins&gt;in tobacco products. Both benign &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;and malignant &lt;/ins&gt;tumors are formed in rodents, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;mice &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;mice &lt;/ins&gt;have already been &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;activated &lt;/ins&gt;by NNK. The &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;focus &lt;/ins&gt;of NNK in conventional smoke has &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;risen &lt;/ins&gt;while those of benzo( a pyrene have &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;decreased because &lt;/ins&gt;the 1960s.The smoke of cigarettes also &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;includes lots &lt;/ins&gt;of free radicals and oxidative damage is caused by free radicals. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Both &lt;/ins&gt;particulate and gas phase are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;highly &lt;/ins&gt;oxidative and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;therefore &lt;/ins&gt;damage the lung. Cigarette &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;smoke &lt;/ins&gt;also triggers proinflammatory cytokines and employees &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;triggered &lt;/ins&gt;macrophagesand neutrophils to lung tissue.Cigarettes &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;have &lt;/ins&gt;a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;very &lt;/ins&gt;high &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;levels &lt;/ins&gt;of materials. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;About &lt;/ins&gt;30 materials have already been identified. Some &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;research &lt;/ins&gt;indicates that &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;metals &lt;/ins&gt;are powerful initiators of the carcinogenic process, but can be likely &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;supporters &lt;/ins&gt;during carcinogenesis. Cigarette smoke contains high &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;degrees &lt;/ins&gt;of cadmium, chromium and also nickel. Chromium &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;accumulates &lt;/ins&gt;in the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;tobacco and &lt;/ins&gt;lung smoking &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;may &lt;/ins&gt;be the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;primary supply &lt;/ins&gt;of cadmium exposure in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;individuals&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Unfortunately &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;contribution &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;the metals &lt;/ins&gt;to lung cancer is poorly understood.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;

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		<author><name>DouglassFell888</name></author>	</entry>

	<entry>
		<id>https://www.8beauty.com/wiki/index.php?title=How_Smoking_Causes_Lung_Cancer&amp;diff=51811&amp;oldid=prev</id>
		<title>2013年4月25日 (四) 06:57 FangLeven1073</title>
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				<updated>2013-04-25T06:57:40Z</updated>
		
		<summary type="html">&lt;p&gt;&lt;/p&gt;
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				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;←上一版本&lt;/td&gt;
				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;2013年4月25日 (四) 06:57的版本&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot; &gt;第1行：&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;第1行：&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;−&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;It's been well-known for &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;entire 2nd 1 / 2 &lt;/del&gt;of the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;20&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;century &lt;/del&gt;that smoking &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;caused &lt;/del&gt;lung cancer. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Smoking not merely advances the risk of &lt;/del&gt;lung cancer &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;among smokers, nevertheless the risk &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;pancreatic cancer&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;esophageal cancer&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;mouth cancer&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;kidney cancer &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;also laryngeal cancer is increased as well&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;These sorts &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cancers &lt;/del&gt;are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;required &lt;/del&gt;to &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;rise among women as a result of their increased levels of smoking&lt;/del&gt;.&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;The heavy use &lt;/del&gt;of tobacco &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;not merely causes various sorts of cancer&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;but it addittionally escalates &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;danger &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;many cardiovascular disorders [http://bestvaporcigarette.org/ smokeless cigarettes health concerns]. In eastern and also main europe more than 400 000 early deaths are brought on by tobacco smoking annually&lt;/del&gt;. The &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;current quantities &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;lung cancer among young men &lt;/del&gt;in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;eastern &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;central europe is higher than in &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;past&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Where &lt;/del&gt;tobacco &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;associated deaths are increasing quite rapidly&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cigarette smoking is however still going up in western and central europe and also in China. Lung cancer is &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;major tobacco&lt;/del&gt;-&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;related growth and &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;key reason behind cancer death &lt;/del&gt;in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;men in just about all developed countries&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Mortality prices &lt;/del&gt;are &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;high&lt;/del&gt;, and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;therefore so are the cultural costs&lt;/del&gt;.&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Cigarette smoking among women &lt;/del&gt;has &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;additionally &lt;/del&gt;increased &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;considerably, because lung cancer is generally critical. More and more girls use up cigarette smoking all over &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;world&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;For &lt;/del&gt;a &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;long time it seemed that the rates &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;lung cancer that tobacco &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;where reduced was not obtaining the same result for girls as it has for men&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;But this has now ended up to be false &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;there is no evidence &lt;/del&gt;that the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;danger of &lt;/del&gt;lung &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cancer because of &lt;/del&gt;smoking &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;is higher in men than in women&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;It takes &lt;/del&gt;quite &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;a while between the exposure and the consequence&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Lung cancer today meets breast cancer while the leading cancer cause &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;death in ladies in Canada, &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;USA&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Scotland, and many other countries&lt;/del&gt;.Cigarette &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;smoking kills half &lt;/del&gt;of &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;those who adopt the pattern&lt;/del&gt;, &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;with half of the death occurring in middle age &lt;/del&gt;and &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;each losing about 20 years of non-smoker's life span&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Lung cancer is obviously &lt;/del&gt;the &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;most typical cause of death but cigarette &lt;/del&gt;smoking could &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;cause death &lt;/del&gt;in &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;24 different ways&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;While it has been increasing in women cigarette smoking in men has been decreasing. And also &lt;/del&gt;the lung cancer &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;rates have increased among women and decreased among men&lt;/del&gt;. &lt;del class=&quot;diffchange diffchange-inline&quot;&gt;Tobacco is a addictive substance, there is no such matter as a &amp;amp;quot;safe&amp;amp;quot; &lt;/del&gt;cigarette&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;, young adults should be persuaded not to smoke and smokers should be urged and helped to avoid. Ideally some time later on we could say &amp;amp;quot;how smoking induced lung cancer&amp;amp;quot; not &amp;amp;quot;how smoking causes lung cancer&lt;/del&gt;.&lt;del class=&quot;diffchange diffchange-inline&quot;&gt;&amp;amp;quot;&lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Lung cancer is just a world wide problem and it is &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;most typical cancer on the planet. The cases &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;lung cancer are unfortuitously increasing every year. It has become swiftly worse in developing and former socialist countries, where smoking rate is still high, even though &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;usage of tobacco has decreased in several high income countries&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Everyone knows &lt;/ins&gt;that smoking &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;causes &lt;/ins&gt;lung cancer &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;but how smoking causes lung cancer is a problem that no one really knows&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;In this essay I will explain how smoking causes &lt;/ins&gt;lung cancer&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;.A cigarette smoking is a very intricate mixture &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;various compounds. A lot more than 4000 different compounds have already been indentified in main-stream cigarette smoke. From these 4000 and a bit more compounds 60-70 are carciongens: heterocyclic hydrocarbons&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;N -heterocyclic amines&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;polycyclic aromatic hydrocarbons (PAH)&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;N -nitrosamines, aromatic amines, normal compounds, aldehydes, inorganic compounds like hydrazine &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;some materials and free radicals&lt;/ins&gt;.&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Tobacco contains a high number &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;N-nitrosamines and PAH-s, which &lt;/ins&gt;are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;which are strong carciogens. Other compounds appear &lt;/ins&gt;to &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;have lower carciogenic potential&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Various studies have shown that PAH-s may cause tumors in laboratory animals. PAH- are formed by imperfect combustion &lt;/ins&gt;of tobacco&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;. Studies have also found that PAH-s could connect to the DNA&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;building mutagenic DNA adducts. And &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;synthesis &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;DNA adducts will be the key initiating event of carciogenesis&lt;/ins&gt;.The &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;focus &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;N-nitrosamines &lt;/ins&gt;in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;tobacco is relatively large &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;heavy smokers have &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;greatest exposure to these ingredients&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;The &lt;/ins&gt;tobacco&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;-specific N -nitrosamines (TSNA)&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;principally &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;nicotine&lt;/ins&gt;-&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;derived NNK, are &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;strongest respiratory carcinogens discovered &lt;/ins&gt;in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;tobacco products&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Both malignant and benign tumors &lt;/ins&gt;are &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;formed in rodents&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;rats &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;hamsters have already been induced by NNK&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;The awareness of NNK in conventional smoke &lt;/ins&gt;has increased &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;while those of benzo( a pyrene have diminished since &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;1960s&lt;/ins&gt;.&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;The smoke of cigarettes also incorporates &lt;/ins&gt;a &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;lot &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;free radicals &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;oxidative damage is caused by free radicals&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;The particulate &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;gas phase are extremely oxidative and for &lt;/ins&gt;that &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;reason damage &lt;/ins&gt;the lung&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;. Cigarette &lt;/ins&gt;smoking &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;also triggers proinflammatory cytokines and employees activated macrophagesand neutrophils to lung tissue&lt;/ins&gt;.&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Cigarettes contain a &lt;/ins&gt;quite &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;high degrees of materials&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Around 30 materials have already been identified. Some evidence indicates that materials are powerful initiators &lt;/ins&gt;of the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;carcinogenic process&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;but can also be likely promoters during carcinogenesis&lt;/ins&gt;. Cigarette &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;smoke contains high levels &lt;/ins&gt;of &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;cadmium&lt;/ins&gt;, &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;chromium &lt;/ins&gt;and &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;also nickel&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Chromium collects in &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;lung and tobacco &lt;/ins&gt;smoking could &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;be the main source of cadmium exposure &lt;/ins&gt;in &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;humans&lt;/ins&gt;. &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;Regrettably &lt;/ins&gt;the &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;factor of those materials to &lt;/ins&gt;lung cancer &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;is poorly understood [http://www&lt;/ins&gt;.&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;bestejuice.net/e-cigar-review-essential-details-in-vapor-&lt;/ins&gt;cigarette&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;-refills-considered-e-cigar-review/ e cigarette carrying case]&lt;/ins&gt;.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;

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		<author><name>FangLeven1073</name></author>	</entry>

	<entry>
		<id>https://www.8beauty.com/wiki/index.php?title=How_Smoking_Causes_Lung_Cancer&amp;diff=51120&amp;oldid=prev</id>
		<title>JorieGodolphin1667：新页面: It's been well-known for the entire 2nd 1 / 2 of the 20. century that smoking caused lung cancer. Smoking not merely advances the risk of lung cancer among smokers, nevertheless the risk ...</title>
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				<updated>2013-04-24T01:18:46Z</updated>
		
		<summary type="html">&lt;p&gt;新页面: It&amp;#039;s been well-known for the entire 2nd 1 / 2 of the 20. century that smoking caused lung cancer. Smoking not merely advances the risk of lung cancer among smokers, nevertheless the risk ...&lt;/p&gt;
&lt;p&gt;&lt;b&gt;新页面&lt;/b&gt;&lt;/p&gt;&lt;div&gt;It's been well-known for the entire 2nd 1 / 2 of the 20. century that smoking caused lung cancer. Smoking not merely advances the risk of lung cancer among smokers, nevertheless the risk of pancreatic cancer, esophageal cancer, mouth cancer, kidney cancer and also laryngeal cancer is increased as well. These sorts of cancers are required to rise among women as a result of their increased levels of smoking.The heavy use of tobacco not merely causes various sorts of cancer, but it addittionally escalates the danger of many cardiovascular disorders [http://bestvaporcigarette.org/ smokeless cigarettes health concerns]. In eastern and also main europe more than 400 000 early deaths are brought on by tobacco smoking annually. The current quantities of lung cancer among young men in eastern and central europe is higher than in the past. Where tobacco associated deaths are increasing quite rapidly, cigarette smoking is however still going up in western and central europe and also in China. Lung cancer is the major tobacco-related growth and the key reason behind cancer death in men in just about all developed countries. Mortality prices are high, and therefore so are the cultural costs.Cigarette smoking among women has additionally increased considerably, because lung cancer is generally critical. More and more girls use up cigarette smoking all over the world. For a long time it seemed that the rates of lung cancer that tobacco and where reduced was not obtaining the same result for girls as it has for men. But this has now ended up to be false and there is no evidence that the danger of lung cancer because of smoking is higher in men than in women. It takes quite a while between the exposure and the consequence. Lung cancer today meets breast cancer while the leading cancer cause of death in ladies in Canada, the USA, Scotland, and many other countries.Cigarette smoking kills half of those who adopt the pattern, with half of the death occurring in middle age and each losing about 20 years of non-smoker's life span. Lung cancer is obviously the most typical cause of death but cigarette smoking could cause death in 24 different ways. While it has been increasing in women cigarette smoking in men has been decreasing. And also the lung cancer rates have increased among women and decreased among men. Tobacco is a addictive substance, there is no such matter as a &amp;amp;quot;safe&amp;amp;quot; cigarette, young adults should be persuaded not to smoke and smokers should be urged and helped to avoid. Ideally some time later on we could say &amp;amp;quot;how smoking induced lung cancer&amp;amp;quot; not &amp;amp;quot;how smoking causes lung cancer.&amp;amp;quot;&lt;/div&gt;</summary>
		<author><name>JorieGodolphin1667</name></author>	</entry>

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