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Fosamax is just a bisphosphonate drug useful for osteoporosis and various other bone disorders. It is marketed alone in addition to in combination with vitamin D underneath the name Fosavance.

Side-effects

GI tract: most prominent are benign negative effects such as for example mild vomiting, dyspepsia, abdominal cramps, wind, diarrhea, or obstipation. A serious side effect is definitely an ulceration of the esophagus brought on by alendronate, which may require intensive treatment and hospitalization. Gastric and duodenal ulceration.

General: rare instances of skin rash, rarely occurring as Stevens-Johnson syndrome and toxic epidermal necrolysis, vision dilemmas (uveitis, scleritis) and generalized muscle, joint, and bone pain (rarely severe) have been seen. In laboratory tests reduced calcium and phosphate values may be obtained but reveal activity of the drug and are benign.

Osteonecrosis of the chin, a side-effect of bisphosphonates.

Dosage

Prophylaxis of osteoporosis in women: 5-10mg daily or 35-70mg weekly.

Therapy of osteoporosis in women and men : 10mg daily or 70mg weekly.

Osteoporosis under corticosteroids: 5mg daily or 35mg weekly in men and premenopausal women or those receiving concomitant HRT. In postmenopausal women not receiving HRT the recommended dose is 10mg daily or 70mg weekly.

Paget's Disease: 40mg daily for a few months.

The drug is usually to be taken only upon rising for the day with a lot of water. Stay, walk or sit half an hour afterward to prevent esophageal injury. At the very least thirty minutes must be waited before meals or other beverages than water are taken in.

Communications

drugs, diet and milk containing high levels of calcium, magnesium or aluminium (antacids ): the resorption of alendronate is diminished. At the least 30 minutes must pass after intake of alendronate before taking the supplement or drug.

Very active vitamin D analogues or fluorides: no data can be acquired. Concomitant treatment should really be avoided.

The additional beneficial aftereffect of HRT (hormone replacement therapy) with estrogens/progestins or raloxifene in postmenopausal women remains to be elucidated, but no connections have now been seen. The combination is therefore possible.

Intravenous ranitidine increases the oral bioavailability of alendronate. No clinical consequences are known.

The mixture of NSAIDS and alendroate increases the risk of gastric ulcers. Both these drugs have the potential to irritate the top of gastro-intestinal mucosa.

Does Merck have a patent on this drug?

Yes, but the patent is set to expire in 2008 and Merck has lost a number of interests block a generic version of the drug from being qualified by the US FDA.

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Disclaimer

The information presented here shouldn't be viewed as medical assistance. Please consult your physician before taking Fosamax or any other drug.

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